XV. Preloading/Postloading

Preloading and postloading involves consuming certain substances in order to prepare your body for the effects of MDMA.

Here are some threads containing pre/postloading recipes from other Bluelighters:
[ www.bluelight.nu ]
[ www.bluelight.nu ]
[ www.bluelight.nu ]

Pre/postloading is usually done during the 24-72 hour period on each side of the roll; and includes one or more of the following:

5HTP – Although not proven to be effective, 5HTP is a precursor to serotonin. 5HTP is available OTC at pharmacies and health stores. Pre/postloading doses usually vary from 100-500mg.

Consumption of 5HTP is both protective and experience-enhancing. For more information, see Bluelight’s 5-HTP FAQ.

Magnesium – Magnesium is a commercially available and natural muscle relaxant. This idea behind using muscle relaxants is to relieve the jaw clenching that can often accompany MDMA use. Preloading doses usually vary from 300-500mg.

Vitamin C – Studies have indicated that Vitamin C can be effective in combating neurotoxicity. Doses usually start at 500mg and go up from there, with 1000-2000mg being a common pre/postloading dose.

Alpha-lipoic Acid – Studies have indicated that ALA can be effective in combating neurotoxicity. The effective dose range for ALA is 500-3000mg.
Study involving ALA and MDMA neurotoxicity

Antacids – The combined effects of drugs, drinking (even water) and dancing can seriously upset stomachs. Having a few Tums handy can preserve a good trip and save you a jog to the loo.

Grapefruit Juice – Grapefruit juice inhibits CYP3A4, which is an enzyme in your digestive system that aids in the metabolism of many drugs. By inhibiting CYP3A4, you are essentially making more MDMA available. Although there is some debate as to what exact component(s) of grapefruit juice have this effect, it is accepted that something in there does the job.

Information on the effects of grapefruit juice can be found here:
[ www.toxi.ch ]
[ www.umich.edu ]
[ www.ualberta.ca ]
[ powernetdesign.com ]

L-Tyrosine and DLPA – While some people advocate preloading with L-Tyrosine and/or DLPA, this idea has been discredited. DLPA is a precursor to L-Tyrosine, and L-Tyrosine is a precursor to dopamine. Much of the speculation about MDMA related neurotoxicity centres on dopamine being taken up through serotonin reuptake transporters.

Other Substances – There are a smattering of other preloading tricks recommended by all sorts of people. The ones listed above are the most key and the most proven.

More information on preloading/postloading can be found here:
[ www.erowid.org ]
[ www.rollinballzcrew.com ]

C. Plugging
Plugging is rectal administration, or putting it up your bum.

[ www.xtc-survey.net ]

On the following pages is a questionnaire for recreational drug users, especially ecstasy-users and former ecstasy-users.


This questionnaire deals with the attitudes of recreational drug users concerning preventive campaigns on ecstasy misuse. Personal data is not available for other persons and will only be used for scientific evaluation within the scope of dissertation.

and cannot afford to buy a full bottle from the net