40 000 Ecstasy Pills!!!
| Good [+1]Toggle ReplyLink» Gamos a répondu le Sun 26 Apr, 2009 @ 6:14pm |
 Coolness: 93525 | [ www.guardian.co.uk ]
The strange case of the man who took 40,000 ecstasy pills in nine years · Usage increased to 25 tablets a day at peak · Memory problems and paranoia may be lasting * David McCandless * The Guardian, Tuesday 4 April 2006 12.56 BST * Article history Doctors from London University have revealed details of what they believe is the largest amount of ecstasy ever consumed by a single person. Consultants from the addiction centre at St George's Medical School, London, have published a case report of a British man estimated to have taken around 40,000 pills of MDMA, the active ingredient in ecstasy, over nine years. The heaviest previous lifetime intake on record is 2,000 pills. Though the man, who is now 37, stopped taking the drug seven years ago, he still suffers from severe physical and mental health side-effects, including extreme memory problems, paranoia, hallucinations and depression. He also suffers from painful muscle rigidity around his neck and jaw which often prevents him from opening his mouth. The doctors believe many of these symptoms may be permanent. The man, known as Mr A in the report in the scientific journal Psychosomatics, started using ecstasy at 21. For the first two years his use was an average of five pills per weekend. Gradually this escalated until he was taking around three and a half pills a day. At the peak, the man was taking an estimated 25 pills every day for four years. After several severe collapses at parties, Mr A decided to stop taking ecstasy. For several months, he still felt he was under the influence of the drug, despite being bedridden. Hallucinations His condition deteriorated and he began to experience recurrent tunnel vision and other problems including hallucinations, paranoia and muscle rigidity. "He came to us after deciding that he couldn't go on any more," said Dr Christos Kouimtsidis, the consultant psychiatrist at St George's Medical School in Tooting who treated him for five months. "He was having trouble functioning in everyday life." The doctors discovered that the man was suffering from severe short-term memory problems of a type usually only seen in lifetime alcoholics. But evaluating the full extent of his condition was difficult as his concentration and attention was so impaired he was unable to follow the simple tasks involved in the test. "This was an exceptional case. His long- term memory was fine but he could not remember day to day things - the time, the day, what was in his supermarket trolley," said Dr Kouimtsidis. "More worryingly, he did not seem aware himself that he had these memory problems." With no mental illness in his family and no prior psychiatric history, the doctors concluded that his unique condition was direct result of his intense ecstasy use. "This is obviously an extreme case so we should not blow any observations out of proportion," says Dr Kouimtsidis. "But if this is what is happening to very heavy users, it might be an indication that daily use of ecstasy over a long period of time can lead to irreversible memory problems and other cognitive deficits." For 10 years, MDMA has been suspected of causing these kinds of effects in heavy users. It is thought to be due to its disruption of the regulation of serotonin, a brain chemical believed to play a role in mood and memory. It remains unclear whether these effects are the result of permanent neurotoxic damage or just temporary reversible alterations in the brain. A special two-part MDMA study in recent issues of the Journal of Psychopharmacology (available online at sagepub), suggests long-term side-effects may be temporary. The researchers from the University Of Louisiana could find no significant relationship between depression and recreational ecstasy use. In the case of Mr A, a structural MRI brain scan failed to show any obvious damage or atrophy in his brain. However, these results, says Dr Kouimtsidis, are difficult to interpret. "A scan of this type is not sensitive enough," he said. Such limitations in brain scanning technology, along with ethical and legal barriers to giving MDMA to human test subjects, have limited direct observation of the drug's effects in humans. Instead, scientists have had to use recreational drug users as subjects in their studies. Conclusions from this are often flawed because few, if any, drugs users use ecstasy in isolation. Cannabis user Mr A was also a heavy cannabis user, and when he was encouraged to decrease his use, his paranoia and hallucinations disappeared and his anxiety abated. But his memory and concentration problems remained, leading the doctors to suspect that these may be permanent disabilities. When he was admitted to a specialist brain injury unit and put on anti-psychotic medication, he did start to show some improvement. "Unfortunately, he discharged himself before we were able to complete the assessment," says Dr Kouimtsidis. "We continued to support him. But he started to use cannabis again and he dropped out. We tried to re-engage him but we lost him about a year ago." The Guardian made several attempts to find the man without success. |
| I'm feeling so long dental plan right now.. | |
| Good [+1]Toggle ReplyLink» basdini a répondu le Mon 27 Apr, 2009 @ 12:30am |
 Coolness: 145230 | well, there you have it don't take 25 caps of mdma in one day... |
| I'm feeling surly right now.. | |
| Good [+1]Toggle ReplyLink» Zaruen a répondu le Mon 27 Apr, 2009 @ 11:04pm |
 Coolness: 50870 | ive heard this story before, see , ecstasy is harmless. |
| Good [+1]Toggle ReplyLink» Sparklz a répondu le Tue 28 Apr, 2009 @ 3:55pm |
 Coolness: 113425 | SHIT! well I just popped 100 caps...it's gonna be quite a day ^.^ |
| I'm feeling naughty right now.. | |
| Good [+1]Toggle ReplyLink» system_glitch a répondu le Tue 28 Apr, 2009 @ 4:27pm |
 Coolness: 162530 | enjoy it for there won't be another.
Oh, wait, ARE YOU OKAY !?!?!?!!! |
| I'm feeling laundering karma right now.. | |
| Good [+1]Toggle ReplyLink» Zaruen a répondu le Tue 28 Apr, 2009 @ 6:34pm |
| Coolness: 50870 | That guy who took 40k ecstasy pills, give him a few more years and i bet you hell be back to normal like he never did any drugs what so ever...... which proves that Ecstasy is HARMLESS@ hahahahaha |
| Good [+1]Toggle ReplyLink» ashleypeace a répondu le Tue 28 Apr, 2009 @ 6:40pm |
 Coolness: 77670 | Holeh FUCK!
thats a shitload of e man...e-tardddddddzzzz |
| I'm feeling like a rockstar right now.. | |
| Good [+1]Toggle ReplyLink» Sparklz a répondu le Wed 29 Apr, 2009 @ 1:30pm |
| Coolness: 113425 | Originally Posted By ZARUEN
That guy who took 40k ecstasy pills, give him a few more years and i bet you hell be back to normal like he never did any drugs what so ever...... which proves that Ecstasy is HARMLESS@ hahahahaha Um, probably not. There are lasting side effects if you consume too much mdma. You deplete your serotonin levels on a massive scale(which can lead to clinical depression), not to mention when you pop e you oxidize the cells in your brain which IS NOT GOOD! Cuz, and I could very well be wrong about this and if I am somebody please correct me, but the cells dont regenerate so once they're fucked its over. Or at least that's what I've been told and have read on ze interwebs. Seriously, go on [ erowid.com ] and look up info before you make assumptions. Pretty much EVERYTHING that we put into our bodies, unless it's 100% organic, has lasting effects. |
| I'm feeling naughty right now.. | |
| Good [+1]Toggle ReplyLink» the_rider a répondu le Wed 29 Apr, 2009 @ 6:19pm |
 Coolness: 42275 | Originally Posted By SPARKLZ
Pretty much EVERYTHING that we put into our bodies, unless it's 100% organic, has lasting effects. Even organic stuff can have lasting effects on the mind and on the body. |
| Good [+1]Toggle ReplyLink» Screwhead a répondu le Wed 29 Apr, 2009 @ 6:34pm |
 Coolness: 685620 | Originally Posted By THE_RIDER
Even organic stuff can have lasting effects on the mind and on the body. QFT the three times I've done shrooms have left more residual effect 6 years later than the 8 months where I spent 1 day a week not on pills.. |
| I'm feeling your norks right now.. | |
| Good [+1]Toggle ReplyLink» Sparklz a répondu le Wed 29 Apr, 2009 @ 7:22pm |
| Coolness: 113425 | Originally Posted By THE_RIDER
Even organic stuff can have lasting effects on the mind and on the body. lovely. So yeah, Zauren, me thinks you should start doing some research if you truly believe that mdma and E have no lasting effects on the body. Mdma is at least pure, E is dirty as shit and you have NO CLUE what`s actually in your pill; unless you bring a testing kit along with you to test every pill you pop and I seriously doubt anybody does that. Seriously though, IF YOU`RE GOING TO CONSUME, AT LEAST BE INFORMED!!!! |
| I'm feeling naughty right now.. | |
| Good [+1]Toggle ReplyLink» Gamos a répondu le Wed 29 Apr, 2009 @ 10:33pm |
| Coolness: 93525 | Originally Posted By SPARKLZ
lovely. So yeah, Zauren, me thinks you should start doing some research if you truly believe that mdma and E have no lasting effects on the body. Mdma is at least pure, E is dirty as shit and you have NO CLUE what`s actually in your pill; unless you bring a testing kit along with you to test every pill you pop and I seriously doubt anybody does that. Seriously though, IF YOU`RE GOING TO CONSUME, AT LEAST BE INFORMED!!!! qft. The basic mechinism of the way E work - releasing serotonin so you feel a rush and then blocking the reuptake of serotonin by binding to the transporters. And its not all that scary. Whats scary IMO are the side effects and the secondary effects of E. The basic side effect, that your body stops making serotonin is minor for the recreational user. This is why you get suicide tuesday. But eventually your body resumes normal production, and you can help it along with bananas and 2htp. As long as your not Eing more than 1ce or 2ce a month, its short term and minor. The long term side effects is that we know E gets broken down into hydrogen peroxide so your body can get rid of it, which kills neurotransmitters axon endings. Serotonin must be shot through the neurotransmitter to feel high. The result is that the highs arent as high, and the lows arent as low. You know how people say it opens them up and makes them a permanently more open person? - it does that by making pain less painful. It also makes love less exhilarating. Those highs and lows you feel are there to stop you from making stupid decisions. If you makes the highs less high and the lows less low, you change the emotional payoffs from decisions. Because people are risk averse, reducing the downside risks and upside risk equally makes people more likely to take more risk. In other words, it makes you more impulsive, which can make you likely to initiate conversations and meet new people if your shy, but can make you a sketch bag if your already fairly impulsive. Heres the thing - If E makes the highs lower and lows higher, in a sense its making you a robot or a zombie. You do it enough and you become like the guy in the article - everything feels the same because the difference between the highest high and the lowest low you can experience are now very small. If thats so, then whats the point of falling in love, or reading, or watching a funny movie or learning something new. Nothing is worth the effort. The secondary effects are the effects it has on your brain's hardwiring. No one is really sure how that works, but it works. Some people say its the oxytocin which is the hormone that lets babies and mothers bond, but its likely more than that. It can alter your brain - how you think, who you are, how you feel, how you frame life - thats why its been so successful in psychotherapy. Again, this can be good or bad depending on how it alters your brain - for the better or for the worse. Thats secondary effect scares me, cuz if you let the time between rolls become long enough, you'll notice the effects of rolling. Zauren, if you want to understand teh extent of these effects of E, dont do it for about 6 months. Then spend a week thinking about who you are and who you want to be, and then roll. Then lay off E for a few months, and youll notice the effect that one roll had on your mind. Its fucking intense. As much as I love rolling, Ive come to appreciate that E is not simply a simulant. Its a powerful, mind-altering drug. IMO its use should be confined to special occasions and times when your in a serious funk like a prolonged depression episode, prolonged apathetic episode, etc. O |
| I'm feeling so long dental plan right now.. | |
| Good [+1]Toggle ReplyLink» Sparklz a répondu le Wed 29 Apr, 2009 @ 11:06pm |
| Coolness: 113425 | Thank you for that Gamos! You pretty much covered everything I wanted to say =) |
| I'm feeling naughty right now.. | |
| Good [+1]Toggle ReplyLink» databoy a répondu le Sat 2 May, 2009 @ 5:33pm |
 Coolness: 106145 | Originally Posted By SPARKLZ
lovely. So yeah, Zauren, me thinks you should start doing some research if you truly believe that mdma and E have no lasting effects on the body. Mdma is at least pure, E is dirty as shit and you have NO CLUE what`s actually in your pill; unless you bring a testing kit along with you to test every pill you pop and I seriously doubt anybody does that. Seriously though, IF YOU`RE GOING TO CONSUME, AT LEAST BE INFORMED!!!! qft but... I consider md.ma to have some quite positive lasting effects on the body and mind. Great memories, thats for sure. I have met some really great peoples and made some lasting friendships from md.ma trips. |
| I'm feeling mexico right now.. | |
| Good [+1]Toggle ReplyLink» Sparklz a répondu le Sun 3 May, 2009 @ 3:11pm |
| Coolness: 113425 | Originally Posted By DATABOY
qft but... I consider md.ma to have some quite positive lasting effects on the body and mind. Great memories, thats for sure. I have met some really great peoples and made some lasting friendships from md.ma trips. I totally agree, some of the times i've spent tripping with my friends are memories that i'll always cherish. The point I was trying to get across is just do not believe that its 100% harmless if you consume a lot. |
| I'm feeling naughty right now.. | |
| Good [+1]Toggle ReplyLink» rave_dolphin a répondu le Tue 5 May, 2009 @ 10:58am |
 Coolness: 86920 | MDMA's secondary effects did hit me hard, but in the good way ! Had highs always too high and lows always dangerously lows. Now I'm more Zen then ever ... though the dreams of working hard, starting companies, becoming millionaire and stuff, they all went to waste.
Can't say if it's for good or bad, it just changed, like it was all natural. Can't even be 100% sure it's the E, just know I've always been burning candles by both ends until I started E 3 years ago. I did for 8 months approximately, once per week-end, half a pill to a pill, and the changes operated in that time-frame. I really believe that psychiatrists should be allowed to prescribe MDMA or at least, allowed to use it on patients in a controlled environement. |
| I'm feeling on fire ! right now.. | |
| Good [+1]Toggle ReplyLink» ashleypeace a répondu le Sun 10 May, 2009 @ 10:06pm |
| Coolness: 77670 | Originally Posted By SPARKLZ
lovely. So yeah, Zauren, me thinks you should start doing some research if you truly believe that mdma and E have no lasting effects on the body. Mdma is at least pure, E is dirty as shit and you have NO CLUE what`s actually in your pill; unless you bring a testing kit along with you to test every pill you pop and I seriously doubt anybody does that. Seriously though, IF YOU`RE GOING TO CONSUME, AT LEAST BE INFORMED!!!! good one there. KNOW YOUR DRUG! ;) |
| I'm feeling :) right now.. | |
| Good [+1]Toggle ReplyLink» Bad_Chemistry a répondu le Fri 15 May, 2009 @ 5:27am |
 Coolness: 73115 | Ha 25 pills a day for 4 years? Something leads me to believe he had that problem before the ecstasy...
Hey man did you pop yet? I'm not sure, I better take another one just to be safe 5 mins later... Hmmm did I take a pill yet... hmm might as well pop another one |
| I'm feeling wtf charles? right now.. | |
| Good [+1]Toggle ReplyLink» Turtle a répondu le Fri 15 May, 2009 @ 12:17pm |
 Coolness: 68335 | Originally Posted By DMTIO
Ha 25 pills a day for 4 years? Something leads me to believe he had that problem before the ecstasy... Hey man did you pop yet? I'm not sure, I better take another one just to be safe 5 mins later... Hmmm did I take a pill yet... hmm might as well pop another one ya i know a guy like that back in the day....he could never remember if he took a pill and would take another one!!! Until someone stopped him which most of the time was me that stopped him... |
| I'm feeling engaged right now.. | |
| Good [+1]Toggle ReplyLink» Sparklz a répondu le Fri 15 May, 2009 @ 4:28pm |
| Coolness: 113425 | Originally Posted By DMTIO
Ha 25 pills a day for 4 years? Something leads me to believe he had that problem before the ecstasy... Hey man did you pop yet? I'm not sure, I better take another one just to be safe 5 mins later... Hmmm did I take a pill yet... hmm might as well pop another one LMFAO! |
| I'm feeling naughty right now.. | |
40 000 Ecstasy Pills!!!
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